During the induced rat lung squamous cell carcinogenesis,deletion of the p16 INK4a gene plays an important role in early stage,the biology activity of p19 ARF is stronger than that of p16 INK4a .

 
  • 在誘發(fā)性大鼠肺鱗癌的發(fā)生發(fā)展中 ,p16 INK4a基因的缺失可能在早期已起作用 ,p19ARF的生物學(xué)活性可能強于p16 INK4a。
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