Doxifluridine was facilely synthesized from 5-fluorouracil in overall yield of 54.6% via trimethyl silylation, condensation, saponification, ketal formation, iodation, hydrogenolysis and hydrolysis.

 
  • 以5-氟尿嘧啶為原料經(jīng)硅醚化、和四乙酰核糖縮合、皂化、酮縮醇形成、碘化、氫解及水解等反應合成了去氧氟尿苷。本法工藝簡(jiǎn)便、條件緩和、原料易得、成本低;總收率達54.;6
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