Diflunisal was prepared from 2,4 difluoroaniline via biphenylation,Friedel Crafts acylation,Baeyer Villiger rearrangement,hydrolysis and carboxylation. The overall yield was 38.4%.
英
美
- 以 2 ；4-二氟苯胺為起始原料 ；經(jīng)聯(lián)苯化作用、Friedel-Crafts?；磻?、Baeyer-Villiger重排、水解和羧基化作用 5步反應制得 2′；4′-二氟 -4-羥基 -(1 ；1′-聯(lián)苯 ) -3 -羧酸 ；總收率可達 3 8.；4%25
