An improved process of pefloxacin mesylate from 1 ethyl 6 fluoro 1,4 dihydro 4 oxoquinoline 3 carboxlic acid was reported.

 
  • 以1乙基6氟7氯1,4二氫4氧代喹啉3羧酸為原料,經(jīng)甲哌嗪化,甲磺酸成鹽得甲磺酸培氟沙星,總收率為826%25。
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