Additionally, P14ARF possesses multiple binding domains to bind to the transcription factor E2F-1 and down-regulates the E2F-l-dependant transcription to prompt cell cycle arrest and induce E2Fl-dependant apoptosis.
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- 另外P14ARF可通過(guò)多個(gè)結合結構域與轉錄因子E2F-1結合,下調E2F-1的轉錄活性,促使細胞周期停滯,引發(fā)E2F-1依賴(lài)性細胞凋亡。