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- Objective To prepare aceclofenac pellet(AFP). 目的 制備醋氯芬酸微丸。
- Aceclofenac was synthesized in 82% overall yield from sodium diclofenac and t-butyl chloroacetate viaesterification and hydrolysis. 雙氯芬酸鈉與氯乙酸叔丁酯經(jīng)酯化、水解反應制得非甾體抗炎藥醋氯芬酸,收率82%25。
- OBJECTIVE：To study the therapeutic effect on adjuvant-induced arthritis and inhibitory effect on delayed type hypersensitivity(DTH) of aceclofenac. 目的：研究醋氯芬酸對佐劑關(guān)節炎大鼠的治療作用及對遲發(fā)型超敏反應的抑制作用。
- Aceclofenac also suppressed DTH with SRBC or PC in mice when it was administered after antigen challenge,but it had no marked effect when administered before antigon challege. 醋氯芬酸于抗原攻擊后給藥，顯著(zhù)抑制SRBC或PC所致小鼠遲發(fā)型超敏反應，而抗原攻擊前給藥則無(wú)明顯作用。
- Method:Aceclofenac was synthesized from chloroacetic acid and benzyl alcohol by esterification to give benzyl chloroacetate,which subjected to condensation and hydrogenolysis. 方法:以氯乙酸為原料,和苯甲醇進(jìn)行酯化反應合成氯代乙酸芐基酯,再經(jīng)縮合、氫解反應制得目標化合物。
- CONCLUSION:Aceclofenac exerted marked therapeutic activity against adjuvant-induced arthritis,associated with its inhibiton to inflammatory response and DTH. 結論：醋氯芬酸對大鼠佐劑關(guān)節炎具有治療作用，其作用機制可能與其抗炎作用及對遲發(fā)型超敏反應的抑制作用有關(guān)。
- On the other hand,the inhibitory effect of aceclofenac on DTH with SRBC or PC was also examined,orally administered before and after antigen challenge,respectively. 此外，分別于抗原攻擊前后給藥，觀(guān)察醋氯芬酸對SRBC或PC所致小鼠遲發(fā)型超敏反應的抑制作用。
- On the base of marketing theory and study method, this paper analyzed Aceclofenac product market, and presented practical and feasible marketing strategic. 本文的寫(xiě)作目的就是應用市場(chǎng)營(yíng)銷(xiāo)的理論與研究方法，對HX公司醋氯芬酸的市場(chǎng)進(jìn)行分析研究，并制定出切實(shí)可行的市場(chǎng)營(yíng)銷(xiāo)策略。
- In this paper, aceclofenac(ACF), a new kind of NSAIDs was selected as the model drug and acrylic pressure sensitive adhesives were used as vehicles to prepare Aceclofenac Transdermal Patches(ATPs). 本文以非甾體抗炎藥醋氯芬酸(aceclofenac，ACF)為模型藥物，研制了以丙烯酸酯類(lèi)壓敏膠為基質(zhì)的醋氯芬酸貼劑(Aceclofenac transdermal patches，ATPs)。
- RESULTS:Aceclofenac significantly inhibited the primary and secondary footpad swelling,diminished the thymic atrophy and enlargement of the spleen and adrealin adjuvant-induced arthritic rats. 結果:醋氯芬酸明顯抑制關(guān)節炎大鼠的原發(fā)性和繼發(fā)性足跖腫脹,并對大鼠的胸腺萎縮、脾臟和腎上腺增重具有對抗作用,其作用強度與等劑量雙氯滅痛相近。
- Sustained-released tablet of aceclofenac 醋氯芬酸緩釋片
- Keywords aceclofenac;plasma;high performance liquid chromatography; 醋氯芬酸;血漿;高效液相色譜;
- Keywords aceclofenac;permeation enhancers;oleic acid;turpentine;azone; 醋氯芬酸;經(jīng)皮滲透;油酸;松節油;氮酮;
- Treatment with aceclofenac on adjuvant-induced arthritis in rats and delayed type hypersensitivity in mice 醋氯芬酸抑制大鼠佐劑關(guān)節炎及小鼠遲發(fā)型超敏反應
- Airtal 乙酰氯芬酸[抗炎藥]
- Aceclofenac 醋氯芬酸, 乙酰氯芬酸[鎮痛抗炎藥]
