AML 1 gene abnormalities, including both chromosome translocation and mutation (point mutation, insertion, deletion mutation, et al), which lead to the lost of transcript activation, are general in acute leukemia.

 
  • 在急性白血病中常見(jiàn)AML1基因結構異常,包括平衡易位及突變(如點(diǎn)突變、插入或缺失突變等),導致AML1的轉錄活性喪失,提示此基因功能缺失在急性白血病的發(fā)生及發(fā)展中起著(zhù)重要作用。
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